FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Smith Edward B III
2. Date of Event Requiring Statement (Month/Day/Year)
07/23/2013
3. Issuer Name and Ticker or Trading Symbol
HEAT BIOLOGICS, INC. [HTBX]
(Last)
(First)
(Middle)
C/O 100 EUROPA DRIVE
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

CHAPEL HILL, NC 27517
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Options 11/22/2010 11/21/2020 Common Stock 5,218 (1) $ 0.48 D  
Options 04/12/2011 04/11/2021 Common Stock 16,305 (2) $ 0.64 D  
Options 04/29/2013 04/28/2023 Common Stock 5,435 (3) $ 8.81 D  
Series A Preferred Stock   (4)   (4) Common Stock 697,303 $ (4) D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Smith Edward B III
C/O 100 EUROPA DRIVE
CHAPEL HILL, NC 27517
  X      
Brightline Ventures III, LLC
C/O 100 EUROPA DRIVE
CHAPEL HILL, NC 27517
    X    

Signatures

/s/ Edward B. Smith 07/23/2013
**Signature of Reporting Person Date

/s/ Brightline Ventures, LLC by Edward B. Smith 07/23/2013
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Fully Vested.
(2) 1/16th vest on the last day of each calendar quarter following the Vesting Commencement Date, s.t. remaining on the Board of Directors. Acceleration upon Change of Control. 9,172 shares are currently vested and exercisable. 1,019 shares will vest at the end of each quarter with the last options vesting on March 31, 2015.
(3) No options are currently vested and exercisable shares. 226 shares shall vest and become exercisable ratably over two years with the last options vesting on July 29, 2015.
(4) The Series A Preferred Stock automatically converts into shares of common stock upon the consummation of an initial public offering resulting in at least $15 million of net proceeds.

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